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Fig. 1 | Neuropsychiatric Electrophysiology

Fig. 1

From: Disturbed theta and gamma coupling as a potential mechanism for visuospatial working memory dysfunction in people with schizophrenia

Fig. 1

a The afterdepolarization (ADP) allows information storage in a single cell. The neuron receives a suprathreshold informational input and a second, subthreshold input that induces the membrane potential to oscillate at theta frequency (negative phase due to inhibition). Simulations show membrane potential before and after informational input (arrowhead). b Network in which pyramidal cells make converging excitatory synapses onto an inhibitory interneuron that produces feedback inhibition of pyramidal cells. c The network can maintain the firing and correct phase of seven groups of cells that are active during different subcycles of the low-frequency oscillation. Each trace illustrates the synchronous firing of a group of cells whose spatial pattern encodes the memory of a letter. The dashed lines during the second and fourth theta cycles show the different subcycles. The limited memory capacity of the network is demonstrated by its failure to store eight memories. Input of the memory X is successful (arrowhead), but R is lost. d If feedback inhibition is removed (arrowhead), the “40-hz” oscillation and phase information is rapidly lost. The two traces represent two of the seven memories stored in the network. A small phase difference (too small to be shown) persists for one cycle after removal of inhibition. Reproduced from [39]

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