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Table 4 RCTs for AD patients

From: Application of transcranial direct current stimulation to psychiatric disorders: trends and perspectives

Author, Year N Arms tDCS protocol Results
Boggio, 2012 (Boggio et al. 2012) 15* tDCS Sham tDCS 5 sessions in a week, 2 mA, 30 min, 35 cm2 Anode: T3 and T4 Cathode: right deltoid muscle Significant improvement of visual recognition memory but no significant effect on MMSE, ADAS-Cog, VAT
Cotelli, 2014 (Cotelli et al. 2014) 36 tDCS + ICMT sham tDCS + ICMT tDCS + motor training 10 sessions in 2 weeks, 2 mA, 25 min, 25cm2 Anode: F3 Cathode: right deltoid muscle No significant improvement in memory except face-name association task
Khedr, 2014 (Khedr et al. 2014) 34 tDCS (Anodal F3 stimulation) tDCS (Cathodal F3 stimulation) sham tDCS 10 sessions in 2 weeks, 2 mA, 25 min, 24 / 100 cm2 Anode: F3 Cathode: right supraorbital region Both anodal and cathodal stimulation showed more significant improvement in MMSE than sham. Reduction of P300 is also observed in tDCS.
Suemoto, 2014 (Suemoto et al. 2014) 40 tDCS sham tDCS 6 sessions in 2 weeks, 2 mA, 30 min, 35 cm2 Anode: F3Cathode: right orbit No significant difference in Apathy, as well as ADAS-Cog and other cognitive tests
  1. ICMT: individual computerized memory training, MMSE: Mini-Mental State Examination, ADAS-Cog: Alzheimer Disease Assessment Scale Cognitive Subscale, VAT: visual attention task
  2. *: crossover