Application of transcranial direct current stimulation to psychiatric disorders: trends and perspectives

Table 2 RCTs of tDCS and CCT for depressed patients

Author, Year	N	Arms	tDCS protocol	Results
Segrave, 2014 (Segrave et al. 2014)	27	CCT + tDCS	5 sessions in one week,	Significantly more change in MADRS and BDI-II over time in CCT + tDCS than others
		Sham CCT + tDCS	2 mA, 24 min, 35 cm²
		CCT + sham tDCS	A/C: F3/F8
Brunoni, 2014 (Brunoni et al. 2014)	37	CCT + tDCS CCT + sham tDCS	10 sessions in two weeks, 2 mA, 30 min, 25 cm² Anode: F3 Cathode: F4	Both groups show recovery after four weeks and non-significantly larger improvement of HDRS and BDI in CCT + sham tDCS
Vanderhasselt, 2015 (Vanderhasselt et al. 2015)	33	CCT + tDCS CCT + sham tDCS	10 sessions in two weeks, 2 mA, 30 min, 25 cm²Anode: F3 Cathode: F4	No significant difference in terms of HDRS and BDI

CCT: cognitive control training, tDCS: transcranial direct current stimulation, A/C: placement of anode/cathode electrodes, MADRS: Montgomery–Åsberg Depression Rating Scale, BDI: Beck depression inventory, HDRS: Hamilton Depression Rating Score

ISSN: 2055-4788