Cross section comparative study for comorbid migraine and major depression in epileptic patients: demographic, clinical, electroencahpalograhy and therapeutic implications

Table 2 Demographic and clinical data for 3 groups of epileptic patients

Variable	Group 1	Group 2	Group 3	Significance
Variable	Epilepsy without comorbidity	Epilepsy with comorbid migraine	Epilepsy with comorbid depression	P value
No (%)	32 (36.78%)	19 (21.83%)	36 (41.37)	0.004
Age range	Age Range	Age range	Age Range	0.000
Mean + SD	21-42 Mean + SD 34 + 6.1	18- 32 Mean + SD 23 + 2.4	20-28 Mean + SD 22 + 1.6	0.000
SEX	SEX	SEX	SEX	0.01
Male :Female	Male :Female	Male :Female	Male :Female
Male :Female	30 : 2	7 : 12	11 :25
Onset of migraine		after epilepsy diagnosis	after epilepsy diagnosis	0.63
		12(63.16%)	28(77.7%)
		before epilepsy diagnosis	before epilepsy diagnosis
		7 (36.84%)	8 (22.22%)
Aura with migraine		+ve 3 (15.7%)		0.361
Aura with migraine		-ve 16 (84.3%)		0.361
Severity of depressive symptoms			Range
			18-25
			HDRS (21 + 3.3)
Drug	Antiepileptic drugs all patients (N = 87)
	Carbamaezepine 34
	lamotirgine 8
	levitracetam 9
	sodium valproate 50
		Antimigraine drugs	selective serotonin reuptake inhibitors (SSRIs) ecitalopram 25 sertraline 11
		triptans (Imigran) 6
		ergot alkaloids (dihydroergotamine and methysergide) 8
		Gabapentin 12
		Pregabalin 9

There was significant difference among group in younger age of onset (p = 0.000) and female gender (p = 0.01) between patient groups with and without comorbid migraine and depression.

ISSN: 2055-4788